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Public studies on ingredients
Animal Study, Bacterial, Human In Vitro, Human Study, In Vitro Study. 

 Ubikinon/Ubiquinol

Research & Studies 

There are 38 good studies at Ubiquinol. Here's a selection:
Abstracts with Ubiquinol Research 

2007
Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21.
Abstract Title:
Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21.
Abstract Source:
Pediatr Neurol. 2007 Dec;37(6):398-403. PMID: 18021919
Abstract Author(s):
Michael V Miles, Bonnie J Patterson, Melinda L Chalfonte-Evans, Paul S Horn, Francis J Hickey, Mark B Schapiro, Paul E Steele, Peter H Tang, Stephanie L Hotze
Article Affiliation:
Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center and University of Cincinnati Medical Center, Cincinnati, OH 45229-3039, USA. michael.miles@cchmc.org
Abstract:
Endogenous coenzyme Q10 is an essential cofactor in the mitochondrial respiratory chain, a potent antioxidant, and a potential biomarker for systemic oxidative status. Evidence of oxidative stress was reported in individuals with trisomy 21. In this study, 14 children with trisomy 21 had significantly increased (P<0.0001) plasma ubiquinone-10 (the oxidized component of coenzyme Q10) compared with 12 age- and sex-matched healthy children (historical controls). Also, the mean ratio of ubiquinol-10 (the biochemically reduced component):total coenzyme Q10 was significantly decreased (P<0.0001). After 3 months of ubiquinol-10 supplementation (10 mg/kg/day) to 10 patients with trisomy 21, the mean ubiquinol-10:total coenzyme Q10 ratio increased significantly (P<0.0001) above baseline values, and 80% of individual ratios were within normal range. No significant or unexpected adverse effects were reported by participants. To our knowledge, this is the first study to indicate that the pro-oxidant state in plasma of children with trisomy 21, as assessed by ubiquinol-10:total coenzyme Q10 ratio, may be normalized with ubiquinol-10 supplementation. Further studies are needed to determine whether correction of this oxidant imbalance improves clinical outcomes of children with trisomy 21.
Article Published Date : Dec 01, 2007
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10 : CK(1234) : AC(183), Ubiquinol : CK(174) : AC(30)
Diseases : Trisomy 21 : CK(10) : AC(1)
__________________________________________
2016
Short-term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise.
Abstract Title:
Short-term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial.
Abstract Source:
Biofactors. 2016 May 19. Epub 2016 May 19. PMID: 27193497
Abstract Author(s):
Alvaro Sarmiento, Javier Diaz-Castro, Mario Pulido-Moran, Jorge Moreno-Fernandez, Naroa Kajarabille, Ignacio Chirosa, Isabel M Guisado, Luis Javier Chirosa, Rafael Guisado, Julio J Ochoa
Article Affiliation:
Alvaro Sarmiento
Abstract:
Studies about Coenzyme Q10 (CoQ10 ) supplementation on strenuous exercise are scarce, especially those related with oxidative stress associated with physical activity and virtually nonexistent with the reduced form, Ubiquinol. The objective of this study was to determine, for the first time, whether a short-term supplementation with Ubiquinol can prevent oxidative stress associated to strenuous exercise. The participants (n = 100 healthy and well trained, but not on an elite level) were classified in two groups: Ubiquinol (experimental group), and placebo group (control). The protocol consisted of conducting two identical strenuous exercise tests with a rest period between tests of 24 h. Blood and urine samples were collected from the participants before supplementation (basal value) (T1), after supplementation (2 weeks) (T2), after first physical exercise test (T3), after 24 h of rest (T4), and after second physical exercise test (T5).The increase observed in the lactate, isoprostanes, DNA damage, and hydroperoxide levels reveals the severity of the oxidative damage induced by the exercise. There was a reduction in the isoprostanes, 8-OHdG, oxidized LDL, and hydroperoxydes in the supplemented Ubiquinol group, an increase in total antioxidant status, fat soluble antioxidant (both plasma and membrane),and CAT activity. Also, NO in the Ubiquinol-supplemented group was maintained within a narrow range. Oxidative stress induced by strenuous exercise is accumulative and increases transiently in subsequent sessions of physical activity. A short-term supplementation (2 weeks) with Ubiquinol (200 mg/day) before strenuous exercise, decreases oxidative stress and increases plasma NO, fact that could improve endothelial function, energetic substrate supply, and muscle recovery after strenuous exercise. © 2016 BioFactors, 2016.
Article Published Date : May 18, 2016
Study Type : Human Study
Additional Links
Substances : Ubiquinol : CK(174) : AC(30)
Diseases : Oxidative Stress : CK(3871) : AC(1382)
Therapeutic Actions : Exercise : CK(1278) : AC(196)
Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)
__________________________________________
2016
Coenzyme Q10 redox state predicts the concentration of c-reactive protein.
__________________________________________You will find much more in the following links on the Ubiquinol:
https://www.ncbi.nlm.nih.gov/pubmed/?term=Ubiquinol
https://www.greenmedinfo.com/substance/ubiquinol

Ubiquinol Reduces Muscle Wasting but Not Fatigue in Tumor-Bearing Mice. Effect of tumor growth and ubiquinol on expression of MAFbx, MuRF1, and BNIP3 mRNA in gastrocnemius muscle (a) and heart (b). Main effect of tumor in gastrocnemius, p < .01. CC = control no drug, n = 16; CU = control/ubiquinol, n = 16; TC = tumor no drug, n = 16; TU = tumor/ubiquinol, n = 16. Yvonne Y. Clark, et al. Biol Res Nurs. ;17(3):321-329
Ubiquinol Reduces Muscle Wasting but Not Fatigue in Tumor-Bearing Mice. Effect of tumor growth and ubiquinol on expression of MAFbx, MuRF1, and BNIP3 mRNA in gastrocnemius muscle (a) and heart (b). Main effect of tumor in gastrocnemius, p < .01. CC = control no drug, n = 16; CU = control/ubiquinol, n = 16; TC = tumor no drug, n = 16; TU = tumor/ubiquinol, n = 16. Yvonne Y. Clark, et al. Biol Res Nurs. ;17(3):321-329
Effect of Ubiquinol on Serum Reproductive Hormones of Amenorrhic Patients. Figure showing the statistically no significant levels of serum Progesterone after Ubiquinol supplementation A. S. Thakur, et al. Indian J Clin Biochem. 2016 Jul;31(3):342-348
Effect of Ubiquinol on Serum Reproductive Hormones of Amenorrhic Patients. Figure showing the statistically no significant levels of serum Progesterone after Ubiquinol supplementation A. S. Thakur, et al. Indian J Clin Biochem. 2016 Jul;31(3):342-348
Three-Year Follow-Up of High-Dose Ubiquinol Supplementation in a Case of Familial Multiple System Atrophy with Compound Heterozygous COQ2 Mutations. CMRO2 images before and after ubiquinol supplementation at 1200 mg/day Jun Mitsui, et al. Cerebellum. 2017;16(3):664-672.
Three-Year Follow-Up of High-Dose Ubiquinol Supplementation in a Case of Familial Multiple System Atrophy with Compound Heterozygous COQ2 Mutations. CMRO2 images before and after ubiquinol supplementation at 1200 mg/day Jun Mitsui, et al. Cerebellum. 2017;16(3):664-672.
Three-Year Follow-Up of High-Dose Ubiquinol Supplementation in a Case of Familial Multiple System Atrophy with Compound Heterozygous COQ2 Mutations. Brain MR images of patient. Upper images were obtained at 60 years of age (before supplementation of ubiquinol), and lower images were obtained at 63 years of age (after 36 months of ubiquinol 1200 mg/day). T1-weighted sagittal images (left) and T2-weightd axial images at the middle regions of the pontine base (right). They show gross atrophy of the infratentorial structures especially in the pons, middle cerebellar peduncle, and cerebellum Jun Mitsui, et al. Cerebellum. 2017;16(3):664-672.
Three-Year Follow-Up of High-Dose Ubiquinol Supplementation in a Case of Familial Multiple System Atrophy with Compound Heterozygous COQ2 Mutations. Brain MR images of patient. Upper images were obtained at 60 years of age (before supplementation of ubiquinol), and lower images were obtained at 63 years of age (after 36 months of ubiquinol 1200 mg/day). T1-weighted sagittal images (left) and T2-weightd axial images at the middle regions of the pontine base (right). They show gross atrophy of the infratentorial structures especially in the pons, middle cerebellar peduncle, and cerebellum Jun Mitsui, et al. Cerebellum. 2017;16(3):664-672.

PubMed
PubMed comprises more than 28 million citations for biomedical literature from MEDLINE, life science journals, and online books.
In PubMed
There are 1862 on Ubiquinol.
There are on Q10 

Ubiquinol
Ubiquinol

11 Pharmacological Actions Researched for Ubiquinol.
Antioxidants744
Neuroprotective Agents416
Anti-Inflammatory Agents413
Cardiotonic Agents110
Fertility Agents: Male110
Interleukin-6 Downregulation110
Neuritogenic110
Renoprotective12
Monocyte chemotattractant protein-1 (MCP-1) Inhibitor11
RANTES (CCL5) Inhibitor11
Tumor Necrosis Factor (TNF) Alpha Inhibitor11

33 Diseases Researched for Ubiquinol
Oxidative Stress431
Heart Failure220
Sperm Quality: Low220
Inflammation414
Asthenozoospermia110
C-Reactive Protein110
Cholesterol: LDL/HDL ratio110
Cholesterol: Oxidation110
Chronic Fatigue Syndrome110
Cognitive Decline/Dysfunction110
Congestive Heart Failure110
Diabetes Mellitus: Type 2110
Diabetes: Glycation/A1C110
Diabetic Polyneuropathy110
Dry Mouth110
High Cholesterol110
Infertility: Male110
Lipid Peroxidation110
Multiple System Atrophy110
Prenatal Nutrition110
Trisomy 21110
Lipopolysaccharide-Induced Toxicity33
Aging12
Antiphospholipid Syndrome12
Brain Injury: Traumatic12
Endothelial Dysfunction12
Kidney Diseases12
Nephropathy12
Parkinson's Disease12
Traumatic Brain Injury12
Ulcerative Colitis12
Gingivitis11
Periodontal Diseases11

The comparison of acquired peer-social behaviour patterns together with plasma ubiquinol.. From: Peer attachment formation by systemic redox regulation with social training after a sensitive period. The behaviour features of various conditions were compared by PCA including serum ubiquinol level. (a) The factor loading vectors of the behaviours of three stages of development. (b) The behaviour data of each condition was compared using the variance ellipses based on PCA of behaviour data and plasma ubiquinol at P21 (blue vector). The distribution of Group F data was significantly different from that of condition A–D and shifted to positive affection (j-call parameter) according to Wilks' lambda analysis (asterisk). (c) Ubiquinol concentration in blood plasma. The significant difference of plasma ubiquinol was observed under two conditions, ubiquinol at high (1200 mg/kg weight·day)with feeding inside of the cage and low (200 mg/kg weight·day) with feeding out (F) by one-way ANOVA and Tukey's post-hoc tests in C (*) and F (double cross). Mamiko Koshiba, et al. Sci Rep. 2013;3:2503
The comparison of acquired peer-social behaviour patterns together with plasma ubiquinol.. From: Peer attachment formation by systemic redox regulation with social training after a sensitive period. The behaviour features of various conditions were compared by PCA including serum ubiquinol level. (a) The factor loading vectors of the behaviours of three stages of development. (b) The behaviour data of each condition was compared using the variance ellipses based on PCA of behaviour data and plasma ubiquinol at P21 (blue vector). The distribution of Group F data was significantly different from that of condition A–D and shifted to positive affection (j-call parameter) according to Wilks' lambda analysis (asterisk). (c) Ubiquinol concentration in blood plasma. The significant difference of plasma ubiquinol was observed under two conditions, ubiquinol at high (1200 mg/kg weight·day)with feeding inside of the cage and low (200 mg/kg weight·day) with feeding out (F) by one-way ANOVA and Tukey's post-hoc tests in C (*) and F (double cross). Mamiko Koshiba, et al. Sci Rep. 2013;3:2503
One Form of CoQ10 Treats Parkinson's, Study Finds
One Form of CoQ10 Treats Parkinson's, Study Finds
A synergistic effect on social attachment formation with mutual interaction and orthomolecular supplementation of ubiquinol.. From: Peer attachment formation by systemic redox regulation with social training after a sensitive period. Attachment formation with MI and ubiquinol. Developmental trajectory was visualised by PCA in 3D time space as the stack of 2D planes at three stages: P13, P16, and P21. The trajectories of each experimental group were colour-coded (Iso in red, Grp in blue, and ubiquinol in black). Ubiquinol was ingested at 0 (vehicle, A, E), 200 (B, D, F), or 1200 (C) [mg/kg weight·day] within the cage (in: A–D) or outside (out: E, F). The behaviour similarity of ubiquinol group with Grp was evaluated by a G ratio based on the Mahalanobis distance (significance was marked with blue bar). Three female and 3 male subjects were used for each condition A–F. Two feeding conditions were set: condition in, within the cage (A–D), or condition out, taking food through a window of the cage (E, F). Mamiko Koshiba, et al. Sci Rep. 2013;3:2503
A synergistic effect on social attachment formation with mutual interaction and orthomolecular supplementation of ubiquinol.. From: Peer attachment formation by systemic redox regulation with social training after a sensitive period. Attachment formation with MI and ubiquinol. Developmental trajectory was visualised by PCA in 3D time space as the stack of 2D planes at three stages: P13, P16, and P21. The trajectories of each experimental group were colour-coded (Iso in red, Grp in blue, and ubiquinol in black). Ubiquinol was ingested at 0 (vehicle, A, E), 200 (B, D, F), or 1200 (C) [mg/kg weight·day] within the cage (in: A–D) or outside (out: E, F). The behaviour similarity of ubiquinol group with Grp was evaluated by a G ratio based on the Mahalanobis distance (significance was marked with blue bar). Three female and 3 male subjects were used for each condition A–F. Two feeding conditions were set: condition in, within the cage (A–D), or condition out, taking food through a window of the cage (E, F). Mamiko Koshiba, et al. Sci Rep. 2013;3:2503
Ubiquinol Reduces Muscle Wasting but Not Fatigue in Tumor-Bearing Mice. Effects of tumor growth and ubiquinol on voluntary running activity. Main effect of tumor, p < .01; day-by-tumor interaction, p = .04. CC = control no drug, n = 11; CU = control/ ubiquinol, n = 12; TC = tumor no drug, n = 12; TU = tumor/ubiquinol, n = 11. Yvonne Y. Clark, et al. Biol Res Nurs. ;17(3):321-329.
Ubiquinol Reduces Muscle Wasting but Not Fatigue in Tumor-Bearing Mice. Effects of tumor growth and ubiquinol on voluntary running activity. Main effect of tumor, p < .01; day-by-tumor interaction, p = .04. CC = control no drug, n = 11; CU = control/ ubiquinol, n = 12; TC = tumor no drug, n = 12; TU = tumor/ubiquinol, n = 11. Yvonne Y. Clark, et al. Biol Res Nurs. ;17(3):321-329.
Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans. Relationship between total CoQ 10 (A), ubiquinol (B), ubiquinone (C) and CoQ 10 redox state (D) and serum GGT activity. Simone Onur, et al. BMC Res Notes. 2014;7:427-427
Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans. Relationship between total CoQ 10 (A), ubiquinol (B), ubiquinone (C) and CoQ 10 redox state (D) and serum GGT activity. Simone Onur, et al. BMC Res Notes. 2014;7:427-427
Ubiquinol supplementation enhances peak power production in trained athletes: a double-blind, placebo controlled study. Individual physical fitness by time point and study group. Individual performance output measured in W/kg bw at time points T1, T2 and T3, stratified by placebo group (Control group) and Ubiquinol group (Experimental group). Dietmar Alf, et al. J Int Soc Sports Nutr. 2013;10:24-24
Ubiquinol supplementation enhances peak power production in trained athletes: a double-blind, placebo controlled study. Individual physical fitness by time point and study group. Individual performance output measured in W/kg bw at time points T1, T2 and T3, stratified by placebo group (Control group) and Ubiquinol group (Experimental group). Dietmar Alf, et al. J Int Soc Sports Nutr. 2013;10:24-24

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