Therapeutic Potential of Hericium erinaceus for Depressive Disorder.

Abstract

Depression is a common and severe neuropsychiatric disorder that is one of the leading causes of global disease burden. Although various anti-depressants are currently available, their efficacies are barely adequate and many have side effects. Hericium erinaceus, also known as Lion's mane mushroom, has been shown to have various health benefits, including antioxidative, antidiabetic, anticancer, anti-inflammatory, antimicrobial, antihyperglycemic, and hypolipidemic effects. It has been used to treat cognitive impairment, Parkinson's disease, and Alzheimer's disease. Bioactive compounds extracted from the mycelia and fruiting bodies of H. erinaceus have been found to promote the expression of neurotrophic factors that are associated with cell proliferation such as nerve growth factors. Although antidepressant effects of H. erinaceus have not been validated and compared to the conventional antidepressants, based on the neurotrophic and neurogenic pathophysiology of depression, H. erinaceus may be a potential alternative medicine for the treatment of depression. This article critically reviews the current literature on the potential benefits of H. erinaceus as a treatment for depressive disorder as well as its mechanisms underlying the antidepressant-like activities.

Keywords: Hericium erinaceus; Lion's mane mushroom; antidepressant; depression; mood disorders.

HEALTH BENEFITS OF MEDICINAL MUSHROOMS

While much attention in recent years has focused on various immunological and anti-cancer properties of certain mushrooms, they also offer other potentially important health benefits, including antioxidants, anti-hypertensive and cholesterol-lowering properties, liver protection, as well as anti-inflammatory, anti-diabetic, anti-viral and anti-microbial properties. These properties have attracted the interest of many pharmaceutical companies, which are viewing the medicinal mushroom as a rich source of innovative biomedical molecules.

SE

Medan mycket uppmärksamhet de senaste åren har fokuserat på olika immunologiska och cancerframkallande egenskaper hos vissa svampar, erbjuder de också andra potentiellt viktiga hälsofördelar, inklusive antioxidanter, antihypertensiva och kolesterolsänkande egenskaper, leverskydd samt antiinflammatoriska , antidiabetiska, antivirala och antimikrobiella egenskaper. Dessa egenskaper har väckt intresse hos många läkemedelsföretag, som ser den medicinska svampen som en rik källa till innovativa biomedicinska molekyler.

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